Substitution mutational signatures in whole-genome-sequenced cancers in the UK population

Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses, revealing mutational signatures, imprints of DNA damage and repair processes that have arisen in each patient’s cancer. We performed mutational signature analyses on 12,222 WGS tumor-normal matched pairs, from patients recru...

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Udgivet i:Science
Main Authors: Degasperi, Andrea, Zou, Xueqing, Amarante, Tauanne Dias, Martinez-Martinez, Andrea, Koh, Gene Ching Chiek, Dias, João M. L., Heskin, Laura, Chmelova, Lucia, Rinaldi, Giuseppe, Wang, Valerie Ya Wen, Nanda, Arjun S., Bernstein, Aaron, Momen, Sophie E., Young, Jamie, Perez-Gil, Daniel, Memari, Yasin, Badja, Cherif, Shooter, Scott, Czarnecki, Jan, Brown, Matthew A., Davies, Helen R., Nik-Zainal, Serena
Format: Artigo
Sprog:Inglês
Udgivet: 2022
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613262/
https://ncbi.nlm.nih.gov/pubmed/35949260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abl9283
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