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TNF induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport
Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species (mROS), which initiate a signaling cascade to cause pathogenic necrosis of mycobacterium-infected macrophages. Here,...
Shranjeno v:
| izdano v: | Science |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2022
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612974/ https://ncbi.nlm.nih.gov/pubmed/35737799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abh2841 |
| Oznake: |
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