TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit

Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish infected with Mycobacterium marinum or Mycobacterium tuberculosis, excess tumor necrosis factor triggers programmed...

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Gepubliceerd in:Cell
Hoofdauteurs: Roca, Francisco J., Whitworth, Laura J., Redmond, Sarah, Jones, Ana A., Ramakrishnan, Lalita
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736209/
https://ncbi.nlm.nih.gov/pubmed/31474371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.08.004
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