Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

ABSTRACT: Locoregional failure (LRF) in patients with breast cancer post-surgery and post-irradiation is linked to a dismal prognosis. In a refined new model, we identified ectonucleotide pyrophosphatase/phosphodiesterase 1/CD203a (ENPP1) to be closely associated with LRF. ENPP1(hi) circulating tumo...

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Publicado en:Cancer Discov
Main Authors: Ruiz-Fernández de Córdoba, Borja, Moreno, Haritz, Valencia, Karmele, Perurena, Naiara, Ruedas, Pablo, Walle, Thomas, Pezonaga-Torres, Alberto, Hinojosa, Juan, Guruceaga, Elisabet, Pineda-Lucena, Antonio, Abengózar-Muela, Marta, Cochonneau, Denis, Zandueta, Carolina, Martínez-Canarias, Susana, Teijeira, Álvaro, Ajona, Daniel, Ortiz-Espinosa, Sergio, Morales, Xabier, Ortiz de Solórzano, Carlos, Santisteban, Marta, Ramos-García, Luis I., Guembe, Laura, Strnad, Vratislav, Heymann, Dominique, Hervás-Stubbs, Sandra, Pío, Rubén, Rodríguez-Ruiz, María E., de Andrea, Carlos E., Vicent, Silvestre, Melero, Ignacio, Lecanda, Fernando, Martínez-Monge, Rafael
Formato: Artigo
Idioma:Inglês
Publicado: American Association for Cancer Research 2022
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612709/
https://ncbi.nlm.nih.gov/pubmed/35191482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-21-0932
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