Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects

Rationale: C5aR1 (CD88), a receptor for complement anaphylatoxin C5a, is a potent immune mediator. Its impact on malignant growth and dissemination of non–small cell lung cancer cells is poorly understood. Objectives: To investigate the contribution of the C5a/C5aR1 axis to the malignant phenotype o...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Ajona, Daniel, Zandueta, Carolina, Corrales, Leticia, Moreno, Haritz, Pajares, María J., Ortiz-Espinosa, Sergio, Martínez-Terroba, Elena, Perurena, Naiara, de Miguel, Fernando J., Jantus-Lewintre, Eloisa, Camps, Carlos, Vicent, Silvestre, Agorreta, Jackeline, Montuenga, Luis M., Pio, Ruben, Lecanda, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6835094/
https://ncbi.nlm.nih.gov/pubmed/29327939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201703-0660OC
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