The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling*1

Hepatic activation of protein kinase C isoforms (PKCs) by diacylglycerol (DAG) promotes insulin resistance and contributes to the development of type 2 diabetes (T2D). The closely related protein kinase D (PKD) isoforms act as effectors for DAG and PKC. Here, we showed that PKD3 was the predominant...

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Gepubliceerd in:Sci Signal
Hoofdauteurs: Mayer, Alexander E., Löffler, Mona C., Valdés, Angel E. Loza, Schmitz, Werner, El-Merahbi, Rabih, Viera, Jonathan Trujillo, Erk, Manuela, Zhang, Thianzhou, Braun, Ursula, Heikenwalder, Mathias, Leitges, Michael, Schulze, Almut, Sumara, Grzegorz
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612146/
https://ncbi.nlm.nih.gov/pubmed/31387939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav9150
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