The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling*1

Hepatic activation of protein kinase C isoforms (PKCs) by diacylglycerol (DAG) promotes insulin resistance and contributes to the development of type 2 diabetes (T2D). The closely related protein kinase D (PKD) isoforms act as effectors for DAG and PKC. Here, we showed that PKD3 was the predominant...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Mayer, Alexander E., Löffler, Mona C., Valdés, Angel E. Loza, Schmitz, Werner, El-Merahbi, Rabih, Viera, Jonathan Trujillo, Erk, Manuela, Zhang, Thianzhou, Braun, Ursula, Heikenwalder, Mathias, Leitges, Michael, Schulze, Almut, Sumara, Grzegorz
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612146/
https://ncbi.nlm.nih.gov/pubmed/31387939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aav9150
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados