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Water Nanoconfined in a Hydrophobic Pore: Molecular Dynamics Simulations of Transmembrane Protein 175 and the Influence of Water Models

Water molecules within biological ion channels are in a nano-confined environment and therefore exhibit behaviours which differ from that of bulk water. Here, we investigate the phenomenon of hydrophobic gating, the process by which a nanopore may spontaneously de-wet to form a ‘vapour lock’ if the...

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Publicat a:ACS Nano
Autors principals: Lynch, Charlotte I., Klesse, Gianni, Rao, Shanlin, Tucker, Stephen J., Sansom, Mark S. P.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612143/
https://ncbi.nlm.nih.gov/pubmed/34784172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.1c06443
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