Wird geladen...

Autocrine Vitamin D-signaling switches off pro-inflammatory programs of Th1 cells

The molecular mechanisms governing orderly shutdown and retraction of CD4(+) T helper (Th)1 responses remain poorly understood. Here, we show that complement triggers contraction of Th1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor (VDR) and the VitD-activating enzyme C...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nat Immunol
Hauptverfasser: Chauss, Daniel, Freiwald, Tilo, McGregor, Reuben, Yan, Bingyu, Wang, Luopin, Nova-Lamperti, Estefania, Kumar, Dhaneshwar, Zhang, Zonghao, Teague, Heather, West, Erin E, Vannella, Kevin M, Ramos-Benitez, Marcos J, Bibby, Jack, Kelly, Audrey, Malik, Amna, Freeman, Alexandra F, Schwartz, Daniella M, Portilla, Didier, Chertow, Daniel S, John, Susan, Lavender, Paul, Kemper, Claudia, Lombardi, Giovanna, Mehta, Nehal N, Cooper, Nichola, Lionakis, Michail S, Laurence, Arian, Kazemian, Majid, Afzali, Behdad
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612139/
https://ncbi.nlm.nih.gov/pubmed/34764490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-01080-3
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!