Autocrine Vitamin D-signaling switches off pro-inflammatory programs of Th1 cells

The molecular mechanisms governing orderly shutdown and retraction of CD4(+) T helper (Th)1 responses remain poorly understood. Here, we show that complement triggers contraction of Th1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor (VDR) and the VitD-activating enzyme C...

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Pubblicato in:Nat Immunol
Autori principali: Chauss, Daniel, Freiwald, Tilo, McGregor, Reuben, Yan, Bingyu, Wang, Luopin, Nova-Lamperti, Estefania, Kumar, Dhaneshwar, Zhang, Zonghao, Teague, Heather, West, Erin E, Vannella, Kevin M, Ramos-Benitez, Marcos J, Bibby, Jack, Kelly, Audrey, Malik, Amna, Freeman, Alexandra F, Schwartz, Daniella M, Portilla, Didier, Chertow, Daniel S, John, Susan, Lavender, Paul, Kemper, Claudia, Lombardi, Giovanna, Mehta, Nehal N, Cooper, Nichola, Lionakis, Michail S, Laurence, Arian, Kazemian, Majid, Afzali, Behdad
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2022
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612139/
https://ncbi.nlm.nih.gov/pubmed/34764490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-01080-3
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