Autocrine Vitamin D-signaling switches off pro-inflammatory programs of Th1 cells

The molecular mechanisms governing orderly shutdown and retraction of CD4(+) T helper (Th)1 responses remain poorly understood. Here, we show that complement triggers contraction of Th1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor (VDR) and the VitD-activating enzyme C...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Chauss, Daniel, Freiwald, Tilo, McGregor, Reuben, Yan, Bingyu, Wang, Luopin, Nova-Lamperti, Estefania, Kumar, Dhaneshwar, Zhang, Zonghao, Teague, Heather, West, Erin E, Vannella, Kevin M, Ramos-Benitez, Marcos J, Bibby, Jack, Kelly, Audrey, Malik, Amna, Freeman, Alexandra F, Schwartz, Daniella M, Portilla, Didier, Chertow, Daniel S, John, Susan, Lavender, Paul, Kemper, Claudia, Lombardi, Giovanna, Mehta, Nehal N, Cooper, Nichola, Lionakis, Michail S, Laurence, Arian, Kazemian, Majid, Afzali, Behdad
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612139/
https://ncbi.nlm.nih.gov/pubmed/34764490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-01080-3
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