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Autocrine Vitamin D-signaling switches off pro-inflammatory programs of Th1 cells
The molecular mechanisms governing orderly shutdown and retraction of CD4(+) T helper (Th)1 responses remain poorly understood. Here, we show that complement triggers contraction of Th1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor (VDR) and the VitD-activating enzyme C...
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| Pubblicato in: | Nat Immunol |
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| Autori principali: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2022
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612139/ https://ncbi.nlm.nih.gov/pubmed/34764490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-01080-3 |
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