An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

Pro-inflammatory immune responses are necessary for effective pathogen clearance, but cause severe tissue damage if not shut down in a timely manner (1,2) . Excessive complement and IFN-γ-associated responses are known drivers of immunopathogenesis (3) and are among the most highly induced immune pr...

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Published in:bioRxiv
Main Authors: McGregor, Reuben, Chauss, Daniel, Freiwald, Tilo, Yan, Bingyu, Wang, Luopin, Nova-Lamperti, Estefania, Zhang, Zonghao, Teague, Heather, West, Erin E, Bibby, Jack, Kelly, Audrey, Malik, Amna, Freeman, Alexandra F, Schwartz, Daniella, Portilla, Didier, John, Susan, Lavender, Paul, Lionakis, Michail S, Mehta, Nehal N, Kemper, Claudia, Cooper, Nichola, Lombardi, Giovanna, Laurence, Arian, Kazemian, Majid, Afzali, Behdad
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388488/
https://ncbi.nlm.nih.gov/pubmed/32743590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.07.18.210161
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