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Reciprocal Transcription Factor Networks Govern Tissue-Resident ILC3 Subset Function and Identity

Innate Lymphoid Cells (ILCs) are guardians of mucosal immunity, yet the transcriptional networks that support their function remain poorly understood. We employed inducible combinatorial deletion of key transcription factors (TFs) required for ILC development (RORγt, RORα and T-bet) to determine the...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Fiancette, Rémi, Finlay, Conor, Willis, Claire, Bevington, Sarah L., Soley, Jake, Ng, Sky T.H., Baker, Syed Murtuza, Andrews, Simon, Hepworth, Matthew R., Withers, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611981/
https://ncbi.nlm.nih.gov/pubmed/34556884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-01024-x
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