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A unified haplotype-based method for accurate and comprehensive variant calling

Almost all haplotype-based variant callers were designed specifically for detecting common germline variation in diploid populations, and give suboptimal results in other scenarios. Here we present Octopus, a variant caller that uses a polymorphic Bayesian genotyping model capable of modeling sequen...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Cooke, Daniel P., Wedge, David C., Lunter, Gerton
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611855/
https://ncbi.nlm.nih.gov/pubmed/33782612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-021-00861-3
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