Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen

Pro-senescence therapies are increasingly being considered for the treatment of cancer. Identifying additional targets to induce senescence in cancer cells could further enable such therapies. However, screening for targets whose suppression induces senescence on a genome-wide scale is challenging,...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Schepers, Arnout, Jochems, Fleur, Lieftink, Cor, Wang, Liqin, Pogacar, Ziva, Leite de Oliveira, Rodrigo, De Conti, Giulia, Beijersbergen, Roderick L., Bernards, Rene
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2021
Assuntos:
Cancer Genes and Networks
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611779/
https://ncbi.nlm.nih.gov/pubmed/34158393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-21-0146
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