A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine. However, targeting glutamine addiction using the glutaminase inhibitor...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Jin, Haojie, Wang, Siying, Zaal, Esther A, Wang, Cun, Wu, Haiqiu, Bosma, Astrid, Jochems, Fleur, Isima, Nikita, Jin, Guangzhi, Lieftink, Cor, Beijersbergen, Roderick, Berkers, Celia R, Qin, Wenxin, Bernards, Rene
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535927/
https://ncbi.nlm.nih.gov/pubmed/33016874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56749
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