SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation

Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation(1). Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites(2), improving insulin sensitivity(3) or promoting an immune tolerant m...

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Pubblicato in:Nat Metab
Autori principali: Bidault, Guillaume, Virtue, Samuel, Petkevicius, Kasparas, Jolin, Helen E., Dugourd, Aurélien, Guénantin, Anne-Claire, Leggat, Jennifer, Mahler-Araujo, Betania, Lam, Brian Y.H., Ma, Marcella K., Dale, Martin, Carobbio, Stefania, Kaser, Arthur, Fallon, Padraic G., Saez-Rodriguez, Julio, McKenzie, Andrew N.J., Vidal-Puig, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611716/
https://ncbi.nlm.nih.gov/pubmed/34531575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-021-00440-5
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