SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation

Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation(1). Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites(2), improving insulin sensitivity(3) or promoting an immune tolerant m...

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Publicado no:Nat Metab
Main Authors: Bidault, Guillaume, Virtue, Samuel, Petkevicius, Kasparas, Jolin, Helen E., Dugourd, Aurélien, Guénantin, Anne-Claire, Leggat, Jennifer, Mahler-Araujo, Betania, Lam, Brian Y.H., Ma, Marcella K., Dale, Martin, Carobbio, Stefania, Kaser, Arthur, Fallon, Padraic G., Saez-Rodriguez, Julio, McKenzie, Andrew N.J., Vidal-Puig, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611716/
https://ncbi.nlm.nih.gov/pubmed/34531575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-021-00440-5
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