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Identification of a quality control factor that monitors failures during proteasome assembly
In eukaryotic cells, half of all proteins function as subunits within multi-protein complexes. Imbalanced synthesis of subunits leads to unassembled intermediates that must be degraded to minimize cellular toxicity. Here, we found that excess PSMC5, a subunit of the proteasome base, was targeted for...
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| Publicado no: | Science |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7611656/ https://ncbi.nlm.nih.gov/pubmed/34446601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc6500 |
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