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Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors
We have used misfolded prion protein (PrP*) as a model to investigate how mammalian cells recognize and degrade misfolded GPI-anchored proteins. While most misfolded membrane proteins are degraded by proteasomes, misfolded GPI-anchored proteins are primarily degraded in lysosomes. Quantitative flow...
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| Izdano u: | eLife |
|---|---|
| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6541436/ https://ncbi.nlm.nih.gov/pubmed/31094677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46740 |
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