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Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

We have used misfolded prion protein (PrP*) as a model to investigate how mammalian cells recognize and degrade misfolded GPI-anchored proteins. While most misfolded membrane proteins are degraded by proteasomes, misfolded GPI-anchored proteins are primarily degraded in lysosomes. Quantitative flow...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Zavodszky, Eszter, Hegde, Ramanujan S
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541436/
https://ncbi.nlm.nih.gov/pubmed/31094677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46740
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