NKX3.1 localization to mitochondria suppresses prostate cancer initiation

Mitochondria provide the front-line of defense against the tumor-promoting effects of oxidative stress. Here we show that the prostate-specific homeoprotein, NKX3.1, suppresses prostate cancer initiation by protecting mitochondria from oxidative stress. Integrating analyses of genetically-engineered...

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Publicat a:Cancer Discov
Autors principals: Papachristodoulou, Alexandros, Rodriguez-Calero, Antonio, Panja, Sukanya, Margolskee, Elizabeth, Virk, Renu K., Milner, Teresa A., Martina, Luis Pina, Kim, Jaime Y., Di Bernardo, Matteo, Williams, Alanna B., Maliza, Elvis A., Caputo, Joseph M., Haas, Christopher, Wang, Vinson, De Castro, Guarionex Joel, Wenske, Sven, Hibshoosh, Hanina, McKiernan, James M., Shen, Michael M., Rubin, Mark A., Mitrofanova, Antonina, Dutta, Aditya, Abate-Shen, Cory
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611624/
https://ncbi.nlm.nih.gov/pubmed/33893149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1765
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