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Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation
The NKX3.1 homeobox gene plays essential roles in prostate differentiation and prostate cancer. We now show that loss-of-function of Nkx3.1 in mouse prostate results in down-regulation of genes that are essential for prostate differentiation, as well as up-regulation of genes that are not normally e...
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| Опубликовано в: : | Science |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5507586/ https://ncbi.nlm.nih.gov/pubmed/27339988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad9512 |
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