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Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation

The NKX3.1 homeobox gene plays essential roles in prostate differentiation and prostate cancer. We now show that loss-of-function of Nkx3.1 in mouse prostate results in down-regulation of genes that are essential for prostate differentiation, as well as up-regulation of genes that are not normally e...

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Pubblicato in:Science
Autori principali: Dutta, Aditya, Le Magnen, Clémentine, Mitrofanova, Antonina, Ouyang, Xuesong, Califano, Andrea, Abate-Shen, Cory
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507586/
https://ncbi.nlm.nih.gov/pubmed/27339988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad9512
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