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Optimal His-Tag Design for Efficient [(99m)Tc(CO)(3)](+) and [(188)Re(CO)(3)](+) Labeling of Proteins for Molecular Imaging and Radionuclide Therapy by Analysis of Peptide Arrays
Hexahistidine tags (His-tags), incorporated into recombinant proteins to facilitate purification using metal-affinity chromatography, are useful binding sites for radiolabeling with [(99m)Tc(CO)(3)](+) and [(188)Re(CO)(3)](+) for molecular imaging and radionuclide therapy. Labeling efficiencies vary...
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| Publicado en: | Bioconjug Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7611356/ https://ncbi.nlm.nih.gov/pubmed/33241692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.0c00561 |
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