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A novel antibody-interleukin-15 fusion protein selectively localizes to tumors, synergizes with TNF-based immunocytokine and inhibits metastasis

Interleukin-15 (IL15) is an immunostimulatory cytokine which holds promises for cancer therapy, but its performance (alone or as partner for fusion proteins) has often been limited by suboptimal accumulation in the tumor and very rapid clearance from circulation. Most recently, the Sushi Domain (SD,...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Corbellari, Riccardo, Stringhini, Marco, Mock, Jaqueline, Ongaro, Tiziano, Villa, Alessandra, Neri, Dario, De Luca, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611336/
https://ncbi.nlm.nih.gov/pubmed/33632875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0853
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