Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade

INTRODUCTION: Cytokine-based products are gaining importance for cancer immunotherapy. L19-TNF is a clinical-stage antibody-cytokine fusion protein that selectively accumulates to tumors and displays potent anticancer activity in preclinical models. Here, we describe an innovative approach to transi...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Dakhel, Sheila, Ongaro, Tiziano, Gouyou, Baptiste, Matasci, Mattia, Villa, Alessandra, Neri, Dario, Cazzamalli, Samuele
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877107/
https://ncbi.nlm.nih.gov/pubmed/31803362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27320
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