Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition

HOTAIR is a lncRNA overexpressed in several epithelial cancers and strongly correlated with invasion. This lncRNA was proven a pivotal element of the epithelial-mesenchymal transition (EMT), a trans-differentiation process triggering metastasis. Snail, master inducer of EMT, requires HOTAIR to recru...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Battistelli, Cecilia, Garbo, Sabrina, Riccioni, Veronica, Montaldo, Claudia, Santangelo, Laura, Vandelli, Andrea, Strippoli, Raffaele, Tartaglia, Gian Gaetano, Tripodi, Marco, Cicchini, Carla
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611326/
https://ncbi.nlm.nih.gov/pubmed/33158813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1764
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