Mutant IDH sensitizes gliomas to endoplasmic reticulum stress and triggers apoptosis via microRNA183-mediated inhibition of Semaphorin 3E

Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2, resulting in the production of the abnormal metabolite D-2 hydroxyglutarate. Here, we studied the effect of mutant IDH on cell proliferation and apoptosis in a glioma mo...

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Udgivet i:Cancer Res
Main Authors: Zhang, Ying, Pusch, Stefan, Innes, James, Sidlauskas, Kastytis, Ellis, Matthew, Lau, Joanne, El-Hassan, Tedani, Aley, Natasha, Launchbury, Francesca, Richard-Loendt, Angela, deBoer, Jasper, Chen, Sheng, Wang, Lei, von Deimling, Andreas, Li, Ningning, Brandner, Sebastian
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611309/
https://ncbi.nlm.nih.gov/pubmed/31391185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0054
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