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O03 IDH1 MUTATIONS IN NEURAL STEM CELLS PROMOTE MIGRATION AND INVASION AND ACT SYNERGISTICALLY WITH P53 AND PTEN LOSS IN MURINE TUMOUR CELLS

INTRODUCTION: Over 70% of low- or high grade gliomas carry IDH1 gene mutations. The understanding of the role of IDH mutations in human glioma cells is limited by concomitant genetic and epigenetic modifications in glioma cell lines, making it difficult to precisely dissect the role of IDH in prolif...

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Detalhes bibliográficos
Main Authors: Sidlauskas, Kastytis, Li, Ningning, Lau, Joanne, Ferreira, Andreia, Brandner, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200946/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou250.3
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