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Reactive oxygen species drive proliferation in acute myeloid leukemia via the glycolytic regulator PFKFB3

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of AML patients and that ROS production promotes proliferat...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Robinson, Andrew J., Hopkins, Goitseone L., Rastogi, Namrata, Hodges, Marie, Doyle, Michelle, Davies, Sara, Hole, Paul S., Omidvar, Nader, Darley, Richard L., Tonks, Alex
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611211/
https://ncbi.nlm.nih.gov/pubmed/31862780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1920
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