Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia

Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the development of acute myeloid leukemia (AML), we compared the nuclear proteome and transcriptome of AML blasts with normal human CD34(+) cells. Ana...

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Опубликовано в: :Leukemia
Главные авторы: Alanazi, Bader, Munje, Chinmay R., Rastogi, Namrata, Williamson, Andrew J. K., Taylor, Samuel, Hole, Paul S., Hodges, Marie, Doyle, Michelle, Baker, Sarah, Gilkes, Amanda F., Knapper, Steven, Pierce, Andrew, Whetton, Anthony D., Darley, Richard L., Tonks, Alex
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995695/
https://ncbi.nlm.nih.gov/pubmed/31611628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0596-4
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