Engineering the human Fc-region enables direct cell killing by cancer glycan-targeting antibodies without the need for immune effector cells or complement

Murine IgG3 glycan-targeting mAb often induces direct cell killing in the absence of immune effector cells or complement via a proinflammatory mechanism resembling oncotic necrosis. This cancer cell killing is due to non-covalent association between Fc regions of neighboring antibodies, resulting in...

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Publicado en:Cancer Res
Main Authors: Vankemmelbeke, Mireille, McIntosh, Richard S., Chua, Jia Xin, Kirk, Thomas, Daniels, Ian, Patsalidou, Marilena, Moss, Robert, Parsons, Tina, Scott, David, Harris, Gemma, Ramage, Judith M., Spendlove, Ian, Durrant, Lindy G.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611157/
https://ncbi.nlm.nih.gov/pubmed/32532823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3599
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