Skin and gut imprinted T helper cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity

Multidimensional single cell-analyses of T cells have fueled the debate about either extensive plasticity or “mixed” priming of T helper cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of priming in the systemic immune compartment is a determinant o...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Hiltensperger, Michael, Beltrán, Eduardo, Kant, Ravi, Tyystjärvi, Sofia, Lepennetier, Gildas, Moreno, Helena Domínguez, Bauer, Isabel J., Grassmann, Simon, Jarosch, Sebastian, Schober, Kilian, Buchholz, Veit R., Kenet, Selin, Gasperi, Christiane, Öllinger, Rupert, Rad, Roland, Muschaweckh, Andreas, Sie, Christopher, Aly, Lilian, Knier, Benjamin, Garg, Garima, Afzali, Ali M., Gerdes, Lisa Ann, Kümpfel, Tania, Franzenburg, Sören, Kawakami, Naoto, Hemmer, Bernhard, Busch, Dirk H., Misgeld, Thomas, Dornmair, Klaus, Korn, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611097/
https://ncbi.nlm.nih.gov/pubmed/34099917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00948-8
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