Mutations in LC3B2 and ATG4A underlie recurrent HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

Recurrent herpesvirus infections can lead to numerous forms of diseases ranging from cold sore and genital herpes to encephalitis. Currently, there is an incomplete understanding of the genetic and immunological factors conferring susceptibility to recurrent HSV2 infections in the central nervous sy...

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Pubblicato in:Sci Immunol
Autori principali: Hait, Alon Schneider, Olagnier, David, Sancho-Shimizu, Vanessa, Skipper, Kristian Alsbjerg, Helleberg, Marie, Larsen, Simon Muller, Bodda, Chiranjeevi, Moldovan, Liviu Ionut, Ren, Fanghui, Brinck-Andersen, Nanna-Sophie, Thomsen, Michelle M., Freytag, Mette Ratzer, Darmalinggam, Sathya, Parkes, Isobel, Kadekar, Darshana D., Rahbek, Stine Hess, van der Horst, Demi, Kristensen, Lasse Sommer, Eriksson, Kristina, Kjems, Jørgen, Mostowy, Serge, Christiansen, Mette, Mikkelsen, Jacob Giehm, Brandt, Christian Thomas, Paludan, Søren R., Mogensen, Trine H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611067/
https://ncbi.nlm.nih.gov/pubmed/33310865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abc2691
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