Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE)

BACKGROUND: DNA transposon-based vectors are effective nonviral tools for gene therapy and genetic engineering of cells. However, promoter DNA methylation and a near-random integration profile, which can result in transgene integration into heterochromatin, renders such vectors vulnerable to transcr...

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Detalhes bibliográficos
Publicado no:BMC Biotechnol
Main Authors: Skipper, Kristian Alsbjerg, Hollensen, Anne Kruse, Antoniou, Michael N., Mikkelsen, Jacob Giehm
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842454/
https://ncbi.nlm.nih.gov/pubmed/31706316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-019-0570-2
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