Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination

RATIONALE: Hypoxia followed by reoxygenation promotes inflammation by activating NF-κB transcription factors in endothelial cells (EC). This process involves modification of the signalling intermediary TRAF6 with polyubiquitin chains. Thus cellular mechanisms that suppress TRAF6 ubiquitination are p...

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Pubblicato in:Circ Res
Autori principali: Luong, Le A., Fragiadaki, Maria, Smith, Jennifer, Boyle, Joseph, Lutz, Jens, Dean, Jonathan L. E., Harten, Sarah, Ashcroft, Margaret, Walmsley, Sarah, Haskard, Dorian O., Maxwell, Patrick H., Walczak, Henning, Pusey, Charles, Evans, Paul C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611065/
https://ncbi.nlm.nih.gov/pubmed/23564640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300119
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