SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin cleavage effects

SARS-CoV-2 is thought to have emerged from bats, possibly via a secondary host. Here we investigate the relationship of spike (S) glycoprotein from SARS-CoV-2 with that of a closely related bat virus, RaTG13. We determined cryo-EM structures for both S proteins, and for SARS-CoV-2, in furin-cleaved...

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I publikationen:Nat Struct Mol Biol
Huvudupphovsmän: Wrobel, Antoni G., Benton, Donald J., Xu, Pengqi, Roustan, Chloё, Martin, Stephen R., Rosenthal, Peter B., Skehel, John J., Gamblin, Steven J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610980/
https://ncbi.nlm.nih.gov/pubmed/32647346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0468-7
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