Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

PURPOSE: The abundance and effects of structural variation at BRCA1/2 in tumours are not well understood. In particular, the impact of these events on homologous recombination repair deficiency (HRD) has yet to be demonstrated. EXPERIMENTAL DESIGN: Exploiting a large collection of whole genome seque...

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Publicado no:Clin Cancer Res
Main Authors: Ewing, Ailith, Meynert, Alison, Churchman, Michael, Grimes, Graeme R., Hollis, Robert L., Herrington, C. Simon, Rye, Tzyvia, Bartos, Clare, Croy, Ian, Ferguson, Michelle, Lennie, Mairi, McGoldrick, Trevor, McPhail, Neil, Siddiqui, Nadeem, Dowson, Suzanne, Glasspool, Rosalind, Mackean, Melanie, Nussey, Fiona, McDade, Brian, Ennis, Darren, McMahon, Lynn, Matakidou, Athena, Dougherty, Brian, March, Ruth, Barrett, J. Carl, McNeish, Iain A., Biankin, Andrew V., Roxburgh, Patricia, Gourley, Charlie, Semple, Colin A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610896/
https://ncbi.nlm.nih.gov/pubmed/33741650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-4068
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