Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations

BACKGROUND: Approximately 10–15% of ovarian carcinomas (OC) are attributed to inherited susceptibility, the majority of which are due to mutations in BRCA1 or BRCA2 (BRCA1/2). These patients display superior clinical outcome, including enhanced sensitivity to platinum-based chemotherapy. Here, we se...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Hollis, Robert L., Meynert, Alison M., Churchman, Michael, Rye, Tzyvia, Mackean, Melanie, Nussey, Fiona, Arends, Mark J., Sims, Andrew H., Semple, Colin A., Herrington, C. Simon, Gourley, Charlie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753521/
https://ncbi.nlm.nih.gov/pubmed/29298688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3981-2
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