A bispecific antibody strategy to target multiple type 2 cytokines in asthma

BACKGROUND: Asthma is a chronic inflammatory airway disease in which innate and adaptive immune cells act together to cause eosinophilic inflammation, goblet cell metaplasia (GCM) and bronchial hyperreactivity (BHR). In clinical trials employing biologicals against interleukin (IL)-4Rα or IL-5, only...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Godar, Marie, Deswarte, Kim, Vergote, Karl, Saunders, Michael, de Haard, Hans, Hammad, Hamida, Blanchetot, Christophe, Lambrecht, Bart N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610797/
https://ncbi.nlm.nih.gov/pubmed/29890236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.06.002
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