The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

BACKGROUND: Genome-wide association studies in asthma have repeatedly identified single nucleotide polymorphisms in the ORM (yeast)-like protein isoform 3 (ORMDL3) gene across different populations. Although the ORM-homologues in yeast are well-known inhibitors of sphingolipid (SL) synthesis, it is...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Debeuf, Nincy, Zhakupova, Assem, Steiner, Regula, Van Gassen, Sofie, Deswarte, Kim, Fayazpour, Farzaneh, Van Moorleghem, Justine, Vergote, Karl, Pavie, Benjamin, Lemeire, Kelly, Hammad, Hamida, Hornemann, Thorsten, Janssens, Sophie, Lambrecht, Bart N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610749/
https://ncbi.nlm.nih.gov/pubmed/31330218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.06.041
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