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Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation

Autophagosomes form de novo in a manner that is incompletely understood. Particularly enigmatic are Atg9 containing vesicles that are required for autophagy machinery assembly but do not supply the bulk of the autophagosomal membrane. Here we reconstituted autophagosome nucleation using recombinant...

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Pubblicato in:Science
Autori principali: Sawa-Makarska, Justyna, Baumann, Verena, Coudevylle, Nicolas, von Bülow, Sören, Nogellova, Veronika, Abert, Christine, Schuschnig, Martina, Graef, Martin, Hummer, Gerhard, Martens, Sascha
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610778/
https://ncbi.nlm.nih.gov/pubmed/32883836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz7714
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