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Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states

RNA polymerase III (Pol III) synthesises tRNAs and other short, essential RNAs. Human Pol III misregulation is linked to tumour transformation, neurodegenerative and developmental disorders, and increased sensitivity to viral infections. Here, we present cryo-EM structures at 2.8 to 3.3 Å resolution...

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Dettagli Bibliografici
Pubblicato in:Nat Struct Mol Biol
Autori principali: Girbig, Mathias, Misiaszek, Agata D., Vorländer, Matthias K., Lafita, Aleix, Grötsch, Helga, Baudin, Florence, Bateman, Alex, Müller, Christoph W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610652/
https://ncbi.nlm.nih.gov/pubmed/33558764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00555-5
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