Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states

RNA polymerase III (Pol III) synthesises tRNAs and other short, essential RNAs. Human Pol III misregulation is linked to tumour transformation, neurodegenerative and developmental disorders, and increased sensitivity to viral infections. Here, we present cryo-EM structures at 2.8 to 3.3 Å resolution...

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Bibliografiset tiedot
Julkaisussa:Nat Struct Mol Biol
Päätekijät: Girbig, Mathias, Misiaszek, Agata D., Vorländer, Matthias K., Lafita, Aleix, Grötsch, Helga, Baudin, Florence, Bateman, Alex, Müller, Christoph W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610652/
https://ncbi.nlm.nih.gov/pubmed/33558764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00555-5
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