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Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states

RNA polymerase III (Pol III) synthesises tRNAs and other short, essential RNAs. Human Pol III misregulation is linked to tumour transformation, neurodegenerative and developmental disorders, and increased sensitivity to viral infections. Here, we present cryo-EM structures at 2.8 to 3.3 Å resolution...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Girbig, Mathias, Misiaszek, Agata D., Vorländer, Matthias K., Lafita, Aleix, Grötsch, Helga, Baudin, Florence, Bateman, Alex, Müller, Christoph W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610652/
https://ncbi.nlm.nih.gov/pubmed/33558764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00555-5
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