Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)–resident protein that plays a crucial role in attenuating ER stress responses. Although MANF is indispensable for the survival and function of mouse β-cells, its precise role in human β-cell development and f...

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Publicat a:Diabetes
Autors principals: Montaser, Hossam, Patel, Kashyap A., Balboa, Diego, Ibrahim, Hazem, Lithovius, Väinö, Näätänen, Anna, Chandra, Vikash, Demir, Korcan, Acar, Sezer, Ben-Omran, Tawfeg, Colclough, Kevin, Locke, Jonathan M., Wakeling, Matthew, Lindahl, Maria, Hattersley, Andrew T., Saarimäki-Vire, Jonna, Otonkoski, Timo
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2021
Matèries:
Genetics/Genomes/Proteomics/Metabolomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610619/
https://ncbi.nlm.nih.gov/pubmed/33500254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db20-1174
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