SARS-CoV-2 evolution during treatment of chronic infection

SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2(1), and is a major antibody target. Here we report chronic SARS-CoV-2 with reduced sensitivity to neutralising antibodies in an immune suppressed individual treated with convalescent plasma, generating whole genome ultra...

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Pubblicato in:Nature
Autori principali: Kemp, Steven A, Collier, Dami A, Datir, Rawlings P, Ferreira, Isabella ATM, Gayed, Salma, Jahun, Aminu, Hosmillo, Myra, Rees-Spear, Chloe, Mlcochova, Petra, Lumb, Ines Ushiro, Roberts, David J, Chandra, Anita, Temperton, Nigel, Sharrocks, Katherine, Blane, Elizabeth, Modis, Yorgo, Leigh, Kendra, Briggs, John, van Gils, Marit, Smith, Kenneth GC, Bradley, John R, Smith, Chris, Doffinger, Rainer, Ceron-Gutierrez, Lourdes, Barcenas-Morales, Gabriela, Pollock, David D, Goldstein, Richard A, Smielewska, Anna, Skittrall, Jordan P, Gouliouris, Theodore, Goodfellow, Ian G, Gkrania-Klotsas, Effrossyni, Illingworth, Christopher JR, McCoy, Laura E, Gupta, Ravindra K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610568/
https://ncbi.nlm.nih.gov/pubmed/33545711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03291-y
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