SARS-CoV-2 evolution during treatment of chronic infection

SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2(1), and is a major antibody target. Here we report chronic SARS-CoV-2 with reduced sensitivity to neutralising antibodies in an immune suppressed individual treated with convalescent plasma, generating whole genome ultra...

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Published in:Nature
Main Authors: Kemp, Steven A, Collier, Dami A, Datir, Rawlings P, Ferreira, Isabella ATM, Gayed, Salma, Jahun, Aminu, Hosmillo, Myra, Rees-Spear, Chloe, Mlcochova, Petra, Lumb, Ines Ushiro, Roberts, David J, Chandra, Anita, Temperton, Nigel, Sharrocks, Katherine, Blane, Elizabeth, Modis, Yorgo, Leigh, Kendra, Briggs, John, van Gils, Marit, Smith, Kenneth GC, Bradley, John R, Smith, Chris, Doffinger, Rainer, Ceron-Gutierrez, Lourdes, Barcenas-Morales, Gabriela, Pollock, David D, Goldstein, Richard A, Smielewska, Anna, Skittrall, Jordan P, Gouliouris, Theodore, Goodfellow, Ian G, Gkrania-Klotsas, Effrossyni, Illingworth, Christopher JR, McCoy, Laura E, Gupta, Ravindra K
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610568/
https://ncbi.nlm.nih.gov/pubmed/33545711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03291-y
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