Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation

SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2, and amino acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics are designed around Wuhan-1 Spike, this raises the theoretical possibility of virus escape, particularly in immunocompr...

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Vydáno v:medRxiv
Hlavní autoři: Kemp, SA, Collier, DA, Datir, R, Ferreira, IATM, Gayed, S, Jahun, A, Hosmillo, M, Rees-Spear, C, Mlcochova, P, Lumb, Ines Ushiro, Roberts, David J, Chandra, Anita, Temperton, N, Sharrocks, K, Blane, E, Briggs, JAG, van, Gils MJ, Smith, KGC, Bradley, JR, Smith, C, Doffinger, R, Ceron-Gutierrez, L, Barcenas-Morales, G, Pollock, DD, Goldstein, RA, Smielewska, A, Skittrall, JP, Gouliouris, T, Goodfellow, IG, Gkrania-Klotsas, E, Illingworth, CJR, McCoy, LE, Gupta, RK
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781345/
https://ncbi.nlm.nih.gov/pubmed/33398302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.05.20241927
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