Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry

We report the synthesis and characterization of novel pentamethylcyclopentadienyl (Cp*) iridium(III) complexes [(Cp*)Ir(4-methyl-4′-carboxy-2,2′-bipyridine)Cl]PF6 (Ir-I), the product (Ir-II) from amide coupling of Ir-I to dibenzocyclooctyne-amine, and its conjugate (Ir-CP) with the cyclic nona-pepti...

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Bibliographic Details
Published in:Inorganica Chim Acta
Main Authors: Zhang, Wen-Ying, Banerjee, Samya, Imberti, Cinzia, Clarkson, Guy J., Wang, Qian, Zhong, Qian, Young, Lawrence S., Romero-Canelón, Isolda, Zeng, Musheng, Habtemariam, Abraha, Sadler, Peter J.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610455/
https://ncbi.nlm.nih.gov/pubmed/33776131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ica.2019.119396
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