Ectopic Humanized Mesenchymal Niche in Mice Enables Robust Engraftment of Myelodysplastic Stem Cells

Myelodysplastic syndromes (MDS) are clonal stem cell diseases characterized mainly by ineffective hematopoiesis. Here, we present an approach that enables robust long-term engraftment of primary MDS stem cells (MDS-SC) in mice by implantation of human mesenchymal cell–seeded scaffolds. Critically fo...

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Veröffentlicht in:Blood Cancer Discov
Hauptverfasser: Mian, Syed A., Abarrategi, Ander, Kong, Kar Lok, Rouault-Pierre, Kevin, Wood, Henry, Oedekoven, Caroline A., Smith, Alexander E., Batsivari, Antoniana, Ariza-McNaughton, Linda, Johnson, Peter, Snoeks, Thomas, Mufti, Ghulam J., Bonnet, Dominique
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for Cancer Research 2020
Schlagworte:
Research Brief
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610449/
https://ncbi.nlm.nih.gov/pubmed/33778768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0161
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