Ectopic Humanized Mesenchymal Niche in Mice Enables Robust Engraftment of Myelodysplastic Stem Cells

Myelodysplastic syndromes (MDS) are clonal stem cell diseases characterized mainly by ineffective hematopoiesis. Here, we present an approach that enables robust long-term engraftment of primary MDS stem cells (MDS-SC) in mice by implantation of human mesenchymal cell–seeded scaffolds. Critically fo...

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Detalles Bibliográficos
Publicado en:Blood Cancer Discov
Autores principales: Mian, Syed A., Abarrategi, Ander, Kong, Kar Lok, Rouault-Pierre, Kevin, Wood, Henry, Oedekoven, Caroline A., Smith, Alexander E., Batsivari, Antoniana, Ariza-McNaughton, Linda, Johnson, Peter, Snoeks, Thomas, Mufti, Ghulam J., Bonnet, Dominique
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for Cancer Research 2020
Materias:
Research Brief
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610449/
https://ncbi.nlm.nih.gov/pubmed/33778768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0161
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