Ectopic Humanized Mesenchymal Niche in Mice Enables Robust Engraftment of Myelodysplastic Stem Cells

Myelodysplastic syndromes (MDS) are clonal stem cell diseases characterized mainly by ineffective hematopoiesis. Here, we present an approach that enables robust long-term engraftment of primary MDS stem cells (MDS-SC) in mice by implantation of human mesenchymal cell–seeded scaffolds. Critically fo...

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Sparad:
Bibliografiska uppgifter
I publikationen:Blood Cancer Discov
Huvudupphovsmän: Mian, Syed A., Abarrategi, Ander, Kong, Kar Lok, Rouault-Pierre, Kevin, Wood, Henry, Oedekoven, Caroline A., Smith, Alexander E., Batsivari, Antoniana, Ariza-McNaughton, Linda, Johnson, Peter, Snoeks, Thomas, Mufti, Ghulam J., Bonnet, Dominique
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for Cancer Research 2020
Ämnen:
Research Brief
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610449/
https://ncbi.nlm.nih.gov/pubmed/33778768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0161
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