Ectopic Humanized Mesenchymal Niche in Mice Enables Robust Engraftment of Myelodysplastic Stem Cells

Myelodysplastic syndromes (MDS) are clonal stem cell diseases characterized mainly by ineffective hematopoiesis. Here, we present an approach that enables robust long-term engraftment of primary MDS stem cells (MDS-SC) in mice by implantation of human mesenchymal cell–seeded scaffolds. Critically fo...

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Detalhes bibliográficos
Publicado no:Blood Cancer Discov
Main Authors: Mian, Syed A., Abarrategi, Ander, Kong, Kar Lok, Rouault-Pierre, Kevin, Wood, Henry, Oedekoven, Caroline A., Smith, Alexander E., Batsivari, Antoniana, Ariza-McNaughton, Linda, Johnson, Peter, Snoeks, Thomas, Mufti, Ghulam J., Bonnet, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2020
Assuntos:
Research Brief
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610449/
https://ncbi.nlm.nih.gov/pubmed/33778768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0161
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