Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

Upon fertilization in mammals the gametes are reprogrammed to create a totipotent zygote, a process that involves de novo establishment of chromatin domains. A major feature occurring during preimplantation development is the dramatic remodeling of constitutive heterochromatin, although the function...

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Pubblicato in:Nat Cell Biol
Autori principali: Burton, Adam, Brochard, Vincent, Galan, Carmen, Ruiz-Morales, Elias R., Rovira, Quirze, Rodriguez-Terrones, Diego, Kruse, Kai, Le Gras, Stéphanie, Udayakumar, Vishnu S., Chin, Hang Gyeong, Eid, André, Liu, Xiaoyu, Wang, Chenfei, Gao, Shaorong, Pradhan, Sriharsa, Vaquerizas, Juan M., Beaujean, Nathalie, Jenuwein, Thomas, Torres-Padilla, Maria-Elena
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610380/
https://ncbi.nlm.nih.gov/pubmed/32601371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0536-6
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