Mutational mechanisms of EZH2 inactivation in myeloid neoplasms

EZH2, a component of the polycomb repressive complex 2, catalyses the trimethylation of histone H3 lysine 27, a chromatin mark associated with transcriptional repression. EZH2 loss-of-function mutations are seen in myeloid neoplasms and are associated with an adverse prognosis. Missense mutations in...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Chase, Andrew, Score, Joannah, Lin, Feng, Bryant, Catherine, Waghorn, Katherine, Yapp, Sarah, Carreno-Tarragona, Gonzalo, Aranaz, Paula, Villasante, Aranzazu, Ernst, Thomas, Cross, Nicholas C. P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610374/
https://ncbi.nlm.nih.gov/pubmed/32322039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0816-y
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